Lisdexamfetamine is a medicine that helps people with two main problems: ADHD (Attention Deficit Hyperactivity Disorder) and binge eating disorder( BED). It is sold under brand names like Vyvanse and Elvanse.
How It Works ?
Lisdexamfetamine is a “prodrug,” which means it only starts working after your body changes it into another substance called dextroamphetamine. This active form helps increase certain chemicals in the brain—like dopamine and norepinephrine—that improve focus, control impulses, and reduce hyperactivity.
For Binge Eating In adults, lisdexamfetamine can also help with binge eating disorder. It helps people feel more in control and less likely to eat large amounts of food quickly. It also helps reduce hunger and improve mood.
How to Take It
This medicine is usually taken once a day in the morning. It comes in capsules or chewable tablets. You can swallow the capsule whole or mix its contents with water or yogurt. It’s best not to take it late in the day because it might make it hard to sleep.
US FDA Approval
New Oral Solution Approved In June 2025, the FDA approved Arynta™, the first-ever oral solution form of lisdexamfetamine. This liquid version (10 mg/mL) offers a new option for people who prefer not to take pills—especially helpful for children and adults with swallowing difficulties.
Side Effects
Some common side effects include:
- Loss of appetite
- Trouble sleeping
- Feeling anxious or irritable
- Nausea or diarrhea
Rare but serious side effects can include heart problems or mental health issues like mania or psychosis. That’s why it’s important to take this medicine only under a doctor’s care.
Whether it is Safe?
Lisdexamfetamine is designed to be harder to misuse than other similar drugs. Because it needs to be changed by the body before it works, it’s less likely to be abused.
New Research
Recent studies show that lisdexamfetamine is very effective for ADHD and binge eating. It may also help with other problems like depression or even addiction to methamphetamine, though more research is needed.
Recent Use
More people around the world are using this medicine as awareness of ADHD and binge eating grows. Doctors are learning more about how to use it safely and effectively.
Conclusion -lisdexamfetamine is a powerful tool for helping people focus better and feel more in control of their eating. With the new oral solution now available, treatment is becoming even more accessible and flexible.it will be more useful for elderly patient and children those who are suffering from ADHD and BED.
Ref-1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/219847s000lbl.pdf
Hi…! Currently, I am working as an Professor at Department of Pharmaceutical Chemistry(H.O.D),The Pharmaceutical College, Barpali, Odisha. I have more than 19 years of teaching & research experience in the field of Chemistry & Pharmaceutical sciences.